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Case studies & Application Notes
Application Note: Prediction of the impact of buffer type with mechanistic simulation
Application to protein purification by IEX chromatography
The proper selection of buffers is essential in the design of ion exchange processes. It was reported that at a given pH and ionic strength, a change in the type of buffer (e.g., acetate to phosphate) may have a dramatic impact on protein separation...
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Case studies & Application Notes
Application Note: Comparison of single column and MCSGP processes with mechanistic simulation
Application to oligonucleotides purification by ion exchange chromatography
The Multicolumn Countercurrent Solvent Gradient Purification (MCSGP) process is a strong possible alternative to single-column chromatography for improving chromatographic process performances. Mechanistic simulations can provide an independent opinion...
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Case studies & Application Notes
Application Note: Design of a multicolumn process for mAb capture
Mechanistic simulation to assess the impact of the number of columns on key performance indicators
There is an increasing interest in using multicolumn processes for the capture of monoclonal antibobies (mAbs) by affinity chromatography . However, selecting and designing the most suitable process is not straightforward. There are indeed a wide...
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Case studies & Application Notes
Application Note: Prediction of an oligonucleotide purification by IEX thanks to simulation and mechanistic modeling
Impact of key operating parameters in a complex process
Designing a chromatographic process requires selecting numerous operating parameters (column dimensions, number of steps, step duration, buffer type, eluent pH, flowrates, gradient slope…)
There is a high interest in using predictive simulation...
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Case studies & Application Notes
Case Study: Increasing yield and safety of a nitration process
Predictive simulations coupling mass & heat transfer
Challenge
40-year old nitration process for the production of an Active Pharmaceutical Ingredient
Highly complex process with low selectivity
Need to enhance competitiveness and improve safety
Methods...
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Case studies & Application Notes
Case Study: Debottlenecking of an esterification process
Development of a mechanistic model accounting for phase equilibria (G/L/S)
Challenge
Established process (> 40 years) for the production of an ester
Debottlenecking
Improving economics (OpEx) while minimizing investment
Methods
Identification of the reaction pathway thanks...
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Case studies & Application Notes
Case Study: Improving an industrial fermentation
Challenge
Scale-up of a industrial fermentation process
Need to improve productivity and process stability
Methods
Establishment of mass balances, calculations of yields and Oxygen Uptake Rates
...
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Case studies & Application Notes
Case Study: Removal of an odorous molecule in a cosmetic product
Process simulations using mechanistic modeling
Challenge
Cosmetic active ingredient manufacturing process
More stringent specifications in terms of the residual concentration of an odorous co-product
Methods
Identification of relevant technologies for the removal...
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Case studies & Application Notes
Case Study: Design and start-up of a continuous purification process
Challenge
Existing pilot batch process for the purification of omega-3 fatty acids from natural oil (11 unit operations)
Shift to an industrial continuous production
Methods
Analysis of the existing batch...
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