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Publications
Bioprocess Simulation: Why the Industry Needs To Embrace Engineering Rather Than Empirical Approaches?
By Roger-Marc Nicoud in Bioprocess International
In 1903, the Wright brothers built the first functioning airplane, and botanist Mikhail Tsvet became the first scientist to use chromatography to separate components of a solution (carotene pigments, in his case).
Now, 120 years later, new airplanes...
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Publications
Purification of Protein by HIC
Mechanistic Modeling for Improving Process Optimization
In collaboration with GSK, this article outlines how a simple chromatographic model can predict the impact of pH and ionic strength on HIC chromatograms.
Hydrophobic interaction chromatography (HIC) is a separation technique widely used for...
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Publications
CALIPSO: revolutionizing the management of bioproduction processes in healthcare
Paris (France) – September 16th, 2021 – Sanofi, Capgemini, Ypso-Facto, GPC Bio, CEA, CentralSupelec announce the launch of the project CALIPSO !
A structuring R&D project for French medical research, financed and coordinated by a consortium of high-profile industrial and public actors.
An essential mobilisation to accelerate access to new treatments at an acceptable cost, to ensure...
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Publications
Process comparison in Ypso-Proxima: EASY by Sanofi vs. classical mAb purification process
Technical and economic evaluation to reduce Cost of Goods
During the last years, alternatives to Protein A purification in mAb downstream processing have raised substantial interest. In parallel, the pharmaceutical industry has a growing need for reliable tools supporting process development and rational decision-making...
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Publications
Antibiotics purification by ion-exchange
The power of mechanistic modeling and predictive simulation
Sometimes you have to change a raw material for various reasons (lack of availability, economic pressure, find alternative sustainable raw material), but this little change can impact significantly your process.
In the below article, you’ll...
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Publications
Oligonucleotides & Peptides
Peptide chemistry: in-silico development tools for an efficient process design
ABSTRACT
This article highlights a new way of thinking for the optimization of Peptide Synthesis. The concept is based on numerical tools to assist the peptide chemists for the choice of the manufacturing route. Process development can be shortened...
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Publications
Advanced SPPS
Discussion on the challenge of large-scale peptide synthesis on solid supports
"Solid-Phase Peptide Synthesis (SPPS) is well established and routinely applied on efficient automatic synthesisers, which are available at laboratory scale. However, manufacturing peptides at industrial scale remains a major challenge, considering...
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Publications
A new era in life sciences software
The fine chemicals and biochemicals industries will evolve towards more digitally designed processes associating experiments, user know-how and mechanistic modeling
"Life sciences industries still use outdated tools and methodologies to develop, optimise and operate their (bio)molecule production processes. Ypso-Facto proposes to take a fresh look at the needs and expectations of this sector.
Digitalisation...
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Publications
Designing affinity chromatographic processes for the capture of antibodies
Part I: A simplified approach
ABSTRACT
Protein A affinity chromatography is a standard technique for the purification of therapeutic antibodies. Recently, multi-column chromatographic processes have emerged to turn classical capture processes into more efficient and continuous...
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Publications
Comparing multi-column chromatographic processes for purifying monosaccharides
Part I: A simplifed approach
ABSTRACT
This work proposes a methodology for comparing different multi-column chromatographic processes (SMB, ISMB, SSMB) for purifying monosaccharides. The first step of the methodology consists in determining the flow rates associated with the...
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Publications
Innovative organic chemistry: a differentiating driver for CMOs
A methodological approach to develop technical competitive advantages
ABSTRACT:
The fine chemicals segment is a field of continuous innovation with regards to new molecular structures in which Contract Manufacturing Organizations (CMOs) play a major role, in particular for the commercial-scale production of organic...
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Publications
From batch to continuous processes: a good answer, but what is the question? Part II*
The purification unit operations, specific situations, the complete process perspective
ABSTRACT:
The switch from batch to continuous process is a major topical question in the fine chemical, pharmaceutical and biopharmaceutical industries. In spite of a genuine interest, as shown by the profusion of recent literature and symposia...
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Publications
From batch to continuous processes: a good answer, but what is the question? Part I*
General considerations and the reaction unit perspective
ABSTRACT:
The switch from batch to continuous process is a major topical question in the fine chemical, pharmaceutical and biopharmaceutical industries. In spite of a genuine interest, as shown by the profusion of recent literature and symposia...
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Publications
A continuum theory for multicomponent chromatography modeling
ABSTRACT:
A continuum theory is proposed for modeling multicomponent chromatographic systems under linear conditions. The model is based on the description of complex mixtures, possibly involving tens or hundreds of solutes, by a continuum. The...
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Publications
The amazing ability of continuous chromatography to adapt to a moving environment
ABSTRACT:
While normally considered an expensive technology, chromatography has been used for very large-scale applications for ∼50 years. Main successes reported in the petrochemical or sugar industries are obtained with systems having the characteristics...
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Publications
Oligonucleotide Purification by Ion Exchange Chromatography : Step-by-Step Guide to Process Understanding, Modeling, and Simulation
Published in OPRD in collaboration with GSK, AstraZeneca and Johnson & Johnson
Check out Ypso-Facto's new publication on oligonuclotide purification by Ion Exchange Chromatography in collaboration with GSK , Astrazeneca and Johnson & Johnson .
ABSTRACT
Oligonucleotides have emerged as a promising class of...
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Publications
Ypso-Facto dans le magazine La Semaine : "L'entreprise biopharmaceutique Ypso-Facto, une réussite de Lorraine" (French)
Dans son dernier numéro, le magazine La Semaine consacre un article à Ypso-Facto. C’est l’occasion pour nous de partager un aperçu de notre travail et de notre engagement dans les secteurs de la chimie et des bioprocédés. L’article aborde...
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