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Small molecules - Neutraceuticals - Antibodies - Antibiotics - Cosmetics - Enzymes - Oligonucleotides - Peptides - ProteinsBlog
Sanofi's experience with mechanistic modeling and Ypso-Ionic
Mechanistic models offer a robust alternative to traditional statistical methods because they require fewer experimental data and provide superior predictive capabilities, even outside of the conditions studied experimentally.
We have implemented...
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Case studies & Application Notes
Application Note: Prediction of the impact of buffer type with mechanistic simulation
Application to protein purification by IEX chromatography
The proper selection of buffers is essential in the design of ion exchange processes. It was reported that at a given pH and ionic strength, a change in the type of buffer (e.g., acetate to phosphate) may have a dramatic impact on protein separation...
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Publications
Purification of Protein by HIC
Mechanistic Modeling for Improving Process Optimization
In collaboration with GSK, this article outlines how a simple chromatographic model can predict the impact of pH and ionic strength on HIC chromatograms.
Hydrophobic interaction chromatography (HIC) is a separation technique widely used for...
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Publications
CALIPSO: revolutionizing the management of bioproduction processes in healthcare
Paris (France) – September 16th, 2021 – Sanofi, Capgemini, Ypso-Facto, GPC Bio, CEA, CentralSupelec announce the launch of the project CALIPSO !
A structuring R&D project for French medical research, financed and coordinated by a consortium of high-profile industrial and public actors.
An essential mobilisation to accelerate access to new treatments at an acceptable cost, to ensure...
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Webinars
Modeling and simulation of ion-exchange in bioprocesses - illustrations from industrial biotech to biopharma
Presented by Yohann Le Guennec
Ion-exchange chromatography is based on the differences in terms of electrostatic interactions of molecules regarding an adsorbent. Nowadays, industrial processes based on ion-exchange chromatography can be found in many different sectors from the food...
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Webinars
Purification of protein by Hydrophobic Interaction Chromatography (HIC): mechanistic modeling for improved understanding and process optimization
Presented by Yohann Le Guennec
Hydrophobic Interaction Chromatography (HIC) is a chromatographic separation technique that is today successfully used for the purification of proteins. However, to achieve highly efficient separations, key operating parameters – like pH and ionic...
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Publications
Process comparison in Ypso-Proxima: EASY by Sanofi vs. classical mAb purification process
Technical and economic evaluation to reduce Cost of Goods
During the last years, alternatives to Protein A purification in mAb downstream processing have raised substantial interest. In parallel, the pharmaceutical industry has a growing need for reliable tools supporting process development and rational decision-making...
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Publications
Continuous Biopharmaceutical Processes
Chromatography, Bioconjugation, and Protein Stability
ABSTRACT:
This innovative reference provides a coherent and critical view on the potential benefits of a transition from batch to continuous processes in the biopharmaceutical industry, with the main focus on chromatography. It also covers the key...
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