Ionic: Designing Chromatographic Processes in a Virtual Lab

Ypso-Ionic® is an application in Ypso-Proxima® to design chromatographic processes.

Mechanistic chromatography modeling

Mechanistic modeling is based on the laws of physics and biochemical principles to predict system behavior and is the most advanced way to speed up chromatography process development, scale-up, and troubleshooting.

Accelerate process understanding

Reduce risk in scale-up and tech transfer

Root cause analysis

About the name IONIC

Bioprocesses use buffers, and these buffers contain ions. Ion concentration and dissociation impact pH which in turns impacts molecules to be purified. Simultaneous interactions with the resin make the system very difficult to model.

Ionic is the only commercial software handling the complexity of ionization mechanisms in connection with chromatography.

This enables prediction of pH waves inside the column, simulation of interconnected columns, and influence of Critical Material Attributes as well as Critical Process Parameters.

Key features

Contextualize experimental data

Features

Define your process (without restrictions in terms of recipe, number of columns, dead volumes, collection tanks, recycling…)
Store your measured results (both online and offline data) with adequate labels and units
Import protocols and data from specific equipment or from historical Excel files.

Benefits

Ensure data standardization, completeness and reusability
Enjoy reliable tech transfer and knowledge management
Allow seamless connection with predictive simulation

Compare and calculate KPIs in one-click

Features

Automatically perform mass balance analysis from your data
Calculate KPIs (yield, purity, eluent consumption, productivity) on pooled fractions
Easily compare experiments

Benefits

Save time
Reduce error-prone manual calculations
Remove ambiguities

Predict the impact of key parameters

Features

Prediction of behaviors in non-explored regions thanks to mechanistic simulation
Examples of operating parameters: loading, flowrate, pH, salt nature and concentration, gradient slope, column dimensions, upflow vs downflow, number of columns

Benefits

Narrow down the space where to focus on with experiments
Think out of the box
Secure scale-up
Perform troubleshooting

A wide range of applications

Ionic can be used for various types of chromatography:
- Ion exchange, adsorption, affinity, hydrophobic interactions, size exclusion, ion exclusion, chelation, etc

… from the simplest to the most complex molecules:
mineral ions, sugars, organic acids, amino acids, oligonucleotides, proteins, monoclonal antibodies, etc

… with any kind of process configuration:
single-column or multicolumn, isocratic or gradient, backflush, with or without recycling, etc