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Mechanistic modeling can help switch from batch to continuous: Myth or Fact?
Fact
Once model parameters have been determined with a single column system , they can be used to perform simulations of multicolumn chromatography (MCC) with any number of columns.
Calculating key performance indicators (KPIs) for both single...
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Case studies & Application Notes
Application Note: Design of a multicolumn process for mAb capture
Mechanistic simulation to assess the impact of the number of columns on key performance indicators
There is an increasing interest in using multicolumn processes for the capture of monoclonal antibobies (mAbs) by affinity chromatography . However, selecting and designing the most suitable process is not straightforward. There are indeed a wide...
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Publications
CALIPSO: revolutionizing the management of bioproduction processes in healthcare
Paris (France) – September 16th, 2021 – Sanofi, Capgemini, Ypso-Facto, GPC Bio, CEA, CentralSupelec announce the launch of the project CALIPSO !
A structuring R&D project for French medical research, financed and coordinated by a consortium of high-profile industrial and public actors.
An essential mobilisation to accelerate access to new treatments at an acceptable cost, to ensure...
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Publications
Process comparison in Ypso-Proxima: EASY by Sanofi vs. classical mAb purification process
Technical and economic evaluation to reduce Cost of Goods
During the last years, alternatives to Protein A purification in mAb downstream processing have raised substantial interest. In parallel, the pharmaceutical industry has a growing need for reliable tools supporting process development and rational decision-making...
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Publications
Designing affinity chromatographic processes for the capture of antibodies
Part I: A simplified approach
ABSTRACT
Protein A affinity chromatography is a standard technique for the purification of therapeutic antibodies. Recently, multi-column chromatographic processes have emerged to turn classical capture processes into more efficient and continuous...
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