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Results found for your search on the term "Oligonucleotides"
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Mechanistic modeling can help switch from batch to continuous: Myth or Fact?
Fact
Once model parameters have been determined with a single column system , they can be used to perform simulations of multicolumn chromatography (MCC) with any number of columns.
Calculating key performance indicators (KPIs) for both single...
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Case studies & Application Notes
Application Note: Comparison of single column and MCSGP processes with mechanistic simulation
Application to oligonucleotides purification by ion exchange chromatography
The Multicolumn Countercurrent Solvent Gradient Purification (MCSGP) process is a strong possible alternative to single-column chromatography for improving chromatographic process performances. Mechanistic simulations can provide an independent opinion...
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Case studies & Application Notes
Application Note: Prediction of an oligonucleotide purification by IEX thanks to simulation and mechanistic modeling
Impact of key operating parameters in a complex process
Designing a chromatographic process requires selecting numerous operating parameters (column dimensions, number of steps, step duration, buffer type, eluent pH, flowrates, gradient slope…)
There is a high interest in using predictive simulation...
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Blog
Article : Digital tools unleash the full potential of oligonucleotide production
Panel Discussion on oligonucleotides in Chemistry Today
By Kilian Kobl - Project Manager at Ypso-Facto
Current oligo manufacturing processes are still somewhat larger scale versions of the initial processes conceived in the lab. Oftentimes, during development of an API, the choice of speed had to be...
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Webinars
Getting your process up to speed with digital tools; purification of oligonucleotides by ion exchange chromatography
Presented by Kilian Kobl and illustrated with real-world examples from AstraZeneca and GSK
Oligonucleotides have emerged as a promising class of pharmaceuticals, leading to a drastically increasing demand. Like peptides, they are typically produced by solid phase synthesis and then purified by reverse-phase chromatography and increasingly...
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Publications
Oligonucleotide Purification by Ion Exchange Chromatography : Step-by-Step Guide to Process Understanding, Modeling, and Simulation
Published in OPRD in collaboration with GSK, AstraZeneca and Johnson & Johnson
Check out Ypso-Facto's new publication on oligonuclotide purification by Ion Exchange Chromatography in collaboration with GSK , Astrazeneca and Johnson & Johnson .
ABSTRACT
Oligonucleotides have emerged as a promising class of...
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