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Webinars

Getting your process up to speed with digital tools; purification of oligonucleotides by ion exchange chromatography

Presented by Kilian Kobl and illustrated with real-world examples from AstraZeneca and GSK

Oligonucleotides have emerged as a promising class of pharmaceuticals, leading to a drastically increasing demand. Like peptides, they are typically produced by solid phase synthesis and then purified by reverse-phase chromatography and increasingly...

Webinars

Building a mechanistic model, guidelines and benefits with a focus on enzymatic reactions.

Presented by Yohann Le Guennec and Airy Tilland

Mechanistic models have provided great outcomes for chemical processes development and optimization in the last decades. However, their underlying equations sometimes appear as cryptic for non-initiated people, which limits their acceptance and use...

Webinars

Modeling and simulation of ion-exchange in bioprocesses - illustrations from industrial biotech to biopharma

Presented by Yohann Le Guennec

Ion-exchange chromatography is based on the differences in terms of electrostatic interactions of molecules regarding an adsorbent. Nowadays, industrial processes based on ion-exchange chromatography can be found in many different sectors from the food...

Webinars

Application of ion-exchange to the purification of multivalent isomers: modeling and simulation

Presented by Lucrèce Nicoud

Ion exchange has been extensively used for many purposes in the medical and pharmaceutical industries over the years. This webinar will present an industrial case study, namely the purification of an amino-glycoside antibiotic produced by fermentation...

Webinars

Purification of protein by Hydrophobic Interaction Chromatography (HIC): mechanistic modeling for improved understanding and process optimization

Presented by Yohann Le Guennec

Hydrophobic Interaction Chromatography (HIC) is a chromatographic separation technique that is today successfully used for the purification of proteins. However, to achieve highly efficient separations, key operating parameters – like pH and ionic...

Webinars

Crystallization of polymorphs: advanced process monitoring, data analysis and mechanistic modeling for improved process understanding and optimization

Presented by Lucrèce Nicoud from Ypso-Facto and Richard Becker and Joe Oliva from Blaze Metrics

Many active pharmaceutical ingredients are known to crystallize in different polymorphic forms; a phenomenon that greatly impacts solubility, bioavailability, color, shape, filterability and tabletability. It is key to produce the targeted polymorph...

Webinars

Associating digital tools and QbD to speed-up process development: a few simple and hopefully rational considerations

By Roger-Marc Nicoud, Ypso-Fcato and Thierry Bastogne, CYBERnano

Regulatory bodies, including the FDA and EMA, are strongly promoting the implementation of QbD: a science and risk-based approach to drug development and manufacturing to increase the success rate, process robustness and eventually product quality. ...

Webinars

Industry 4.0 : Using predictive digital tools to speed-up process development.

A few simple and hopefully rational considerations.

In terms of digitalization, the biotech industries are quite significantly behind others, like the automotive or aeronautical industries, possibly because the digital tools available are not very well suited to their needs. Roger-Marc explains how...

Webinars

Deuterium in the 21st century, use in medicinal chemistry and synthetic methods.

Presented by Thomas Jennequin

Ninety years after its discovery, Deuterium is in the spotlights. Since the beginning of the 21 st century, a number of biotechnology companies have successfully explored its potential in drug candidates and generated intellectual property. This approach...

Publications

Understanding ion-exchange chromatography to design efficient processes with a predictive approach

IEX webinar

Ion-exchange chromatography is certainly the most ancient type of chromatography. While M. Tswett is often credited with the paternity of chromatography, the first traces of the use of ion-exchange chromatography date back to Ancient Egypt where it was...

Publications

Designing Robust Chromatographic Processes with a Proven Predictive Approach

Webinar by David Pfister

Preparative chromatography is a versatile purification technique used in various industrial sectors including petrochemistry, sugar production, pharmaceutical and fine chemistry, to name only a few. While this technology is often considered complex,...

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