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Comparison of single and multi-column processes with mechanistic simulation
Application to oligonucleotide purification by ion exchange
Multicolumn Chromatography is a strong possible alternative to single-column chromatography for improving process performances. Mechanistic simulations can be used to investigate several process options and quantify the impact on key performance...
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Boosting a process with digital tools: Purification of oligonucleotides by ion exchange
With GSK and Astrazeneca
Purification of oligonucleotides by ion exchange (IEX) is complex and many operating parameters need to be selected. There is a high interest in developing digital tools allowing to speed up process development, securing scale-up and decreasing waste...
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