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Results found for your search on the term "Multicolumn Chromatography"
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Mechanistic modeling can help switch from batch to continuous: Myth or Fact?
Fact
Once model parameters have been determined with a single column system , they can be used to perform simulations of multicolumn chromatography (MCC) with any number of columns.
Calculating key performance indicators (KPIs) for both single...
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Blog
Reduced experimental work by 4 compared to DoE for an oligonucleotide ion exchange process
Customer Success Story from GSK
" GSK Engaged Ypso-Facto’s expertise, their Ypso-Ionic software and GPX approach to develop a mechanistic model of a complex ion-exchange purification process.
Compared with the classical statistical DoE approach, only 25% of the experimental...
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Doubled productivity of a multi-column ion exchange chromatographic process with increased purity
Customer Success Story from Aker BioMarine
About the optimization of a multi-column Ion Exchange system :
« In combination with AKBM “user-knowledge” and intuition, Ypso-Facto used experimental laboratory- and production-data and made simulation-models with the software...
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Case studies & Application Notes
Application Note: Comparison of single column and MCSGP processes with mechanistic simulation
Application to oligonucleotides purification by ion exchange chromatography
The Multicolumn Countercurrent Solvent Gradient Purification (MCSGP) process is a strong possible alternative to single-column chromatography for improving chromatographic process performances. Mechanistic simulations can provide an independent opinion...
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Case studies & Application Notes
Application Note: Design of a multicolumn process for mAb capture
Mechanistic simulation to assess the impact of the number of columns on key performance indicators
There is an increasing interest in using multicolumn processes for the capture of monoclonal antibobies (mAbs) by affinity chromatography . However, selecting and designing the most suitable process is not straightforward. There are indeed a wide...
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Publications
Designing affinity chromatographic processes for the capture of antibodies
Part I: A simplified approach
ABSTRACT
Protein A affinity chromatography is a standard technique for the purification of therapeutic antibodies. Recently, multi-column chromatographic processes have emerged to turn classical capture processes into more efficient and continuous...
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Publications
Comparing multi-column chromatographic processes for purifying monosaccharides
Part I: A simplifed approach
ABSTRACT
This work proposes a methodology for comparing different multi-column chromatographic processes (SMB, ISMB, SSMB) for purifying monosaccharides. The first step of the methodology consists in determining the flow rates associated with the...
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Publications
The amazing ability of continuous chromatography to adapt to a moving environment
ABSTRACT:
While normally considered an expensive technology, chromatography has been used for very large-scale applications for ∼50 years. Main successes reported in the petrochemical or sugar industries are obtained with systems having the characteristics...
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