Protein A afﬁnity chromatography is a standard technique for the puriﬁcation of therapeutic antibodies. Recently, multi-column chromatographic processes have emerged to turn classical capture processes into more efﬁcient and continuous systems. The design of such chromatographic processes, be they single-column or multi-column systems, is described in this work. A rational method to conceive, scale-up and compare processes is proposed and illustrated with different examples. All along this article, the results of the equilibrium theory... Read more
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