A new era in life sciences software

The fine chemicals and biochemicals industries will evolve towards more digitally designed processes associating experiments, user know-how and mechanistic modeling

Marc-Olivier Simon, Aline Devoille

• by Ypso-Facto
• November 22, 2018

"Life sciences industries still use outdated tools and methodologies to develop, optimise and operate their (bio)molecule production processes. Ypso-Facto proposes to take a fresh look at the needs and expectations of this sector. Digitalisation or digital transformation is ubiquitous in discussions...

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Continuous Biopharmaceutical Processes

Chromatography, Bioconjugation, and Protein Stability

David Pfister, Lucrèce Nicoud, Massimo Morbidelli

• by Ypso-Facto
• September 22, 2018

ABSTRACT: This innovative reference provides a coherent and critical view on the potential benefits of a transition from batch to continuous processes in the biopharmaceutical industry, with the main focus on chromatography. It also covers the key topics of protein stability and protein conjugation...

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Designing Robust Chromatographic Processes with a Proven Predictive Approach

Webinar by David Pfister

• by Ypso-Facto
• June 06, 2018

Preparative chromatography is a versatile purification technique used in various industrial sectors including petrochemistry, sugar production, pharmaceutical and fine chemistry, to name only a few. While this technology is often considered complex, expensive and sometimes not scalable, industrial success...

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Designing affinity chromatographic processes for the capture of antibodies

Part I: A simplified approach

D. Pfister, L. David, M. Holzer, R.-M. Nicoud*

• by Ypso-Facto
• March 22, 2017

ABSTRACT Protein A affinity chromatography is a standard technique for the purification of therapeutic antibodies. Recently, multi-column chromatographic processes have emerged to turn classical capture processes into more efficient and continuous systems. The design of such chromatographic...

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Comparing multi-column chromatographic processes for purifying monosaccharides

Part I: A simplifed approach

Laurent David, Jay Yun, Roger-Marc Nicoud*

• by Ypso-Facto
• March 14, 2017

ABSTRACT This work proposes a methodology for comparing different multi-column chromatographic processes (SMB, ISMB, SSMB) for purifying monosaccharides. The first step of the methodology consists in determining the flow rates associated with the different processes assuming that the columns are...

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