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Process comparison in Ypso-Proxima: EASY by Sanofi vs. classical mAb purification process
Technical and economic evaluation to reduce Cost of Goods
Thomas Prouzeau, Jerome Pezzini, and Benoit Mothes
During the last years, alternatives to Protein A purification in mAb downstream processing have raised substantial interest. In parallel, the pharmaceutical industry has a growing need for reliable tools supporting process development and rational decision-making. This article [1] illustrates the...
Antibiotics purification by ion-exchange
The power of mechanistic modeling and predictive simulation
Lucrèce Nicoud, Karen-Vanessa Gonzalez, Aude Portier, and Roger-Marc Nicoud
Sometimes you have to change a raw material for various reasons (lack of availability, economic pressure, find alternative sustainable raw material), but this little change can impact significantly your process. In the below article, you’ll see how some well-designed experiments and mechanistic...
Oligonucleotides & Peptides
Peptide chemistry: in-silico development tools for an efficient process design
Olivier Ludemann-Hombourger of PolyPeptide Laboratories and N. Petitjean of Ypso-Facto
ABSTRACT This article highlights a new way of thinking for the optimization of Peptide Synthesis. The concept is based on numerical tools to assist the peptide chemists for the choice of the manufacturing route. Process development can be shortened without compromising on process performance and...
Advanced SPPS
Discussion on the challenge of large-scale peptide synthesis on solid supports
Olivier Ludemann-Hombourger of PolyPeptide Laboratories and N. Petitjean of Ypso-Facto
"Solid-Phase Peptide Synthesis (SPPS) is well established and routinely applied on efficient automatic synthesisers, which are available at laboratory scale. However, manufacturing peptides at industrial scale remains a major challenge, considering the complexity of these multi-step syntheses, the...
Understanding ion-exchange chromatography to design efficient processes with a predictive approach
IEX webinar
Ion-exchange chromatography is certainly the most ancient type of chromatography. While M. Tswett is often credited with the paternity of chromatography, the first traces of the use of ion-exchange chromatography date back to Ancient Egypt where it was used to desalt sea water. Nowadays, industrial...
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