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Application Note: Prediction of the impact of buffer type with mechanistic simulation
Application to protein purification by IEX chromatography
The proper selection of buffers is essential in the design of ion exchange processes. It was reported that at a given pH and ionic strength, a change in the type of buffer (e.g., acetate to phosphate) may have a dramatic impact on protein separation. This study aims at assessing whether mechanistic...
Application Note: Comparison of single column and MCSGP processes with mechanistic simulation
Application to oligonucleotides purification by ion exchange chromatography
The Multicolumn Countercurrent Solvent Gradient Purification (MCSGP) process is a strong possible alternative to single-column chromatography for improving chromatographic process performances. Mechanistic simulations can provide an independent opinion as to what criteria can be improved, and a...
Application Note: Design of a multicolumn process for mAb capture
Mechanistic simulation to assess the impact of the number of columns on key performance indicators
There is an increasing interest in using multicolumn processes for the capture of monoclonal antibobies (mAbs) by affinity chromatography . However, selecting and designing the most suitable process is not straightforward. There are indeed a wide range of process configurations, with processes ranging...
Application Note: Prediction of an oligonucleotide purification by IEX thanks to simulation and mechanistic modeling
Impact of key operating parameters in a complex process
Designing a chromatographic process requires selecting numerous operating parameters (column dimensions, number of steps, step duration, buffer type, eluent pH, flowrates, gradient slope…) There is a high interest in using predictive simulation to predict the impact of key operating parameters...
Case Study: Increasing yield and safety of a nitration process
Predictive simulations coupling mass & heat transfer
Challenge 40-year old nitration process for the production of an Active Pharmaceutical Ingredient Highly complex process with low selectivity Need to enhance competitiveness and improve safety Methods Analysis of existing performances and...
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