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Antibiotics purification by ion-exchange
The power of mechanistic modeling and predictive simulation
Lucrèce Nicoud, Karen-Vanessa Gonzalez, Aude Portier, and Roger-Marc Nicoud
Sometimes you have to change a raw material for various reasons (lack of availability, economic pressure, find alternative sustainable raw material), but this little change can impact significantly your process. In the below article, you’ll see how some well-designed experiments and mechanistic...
Oligonucleotides & Peptides
Peptide chemistry: in-silico development tools for an efficient process design
Olivier Ludemann-Hombourger of PolyPeptide Laboratories and N. Petitjean of Ypso-Facto
ABSTRACT This article highlights a new way of thinking for the optimization of Peptide Synthesis. The concept is based on numerical tools to assist the peptide chemists for the choice of the manufacturing route. Process development can be shortened without compromising on process performance and...
Advanced SPPS
Discussion on the challenge of large-scale peptide synthesis on solid supports
Olivier Ludemann-Hombourger of PolyPeptide Laboratories and N. Petitjean of Ypso-Facto
"Solid-Phase Peptide Synthesis (SPPS) is well established and routinely applied on efficient automatic synthesisers, which are available at laboratory scale. However, manufacturing peptides at industrial scale remains a major challenge, considering the complexity of these multi-step syntheses, the...
Understanding ion-exchange chromatography to design efficient processes with a predictive approach
IEX webinar
Ion-exchange chromatography is certainly the most ancient type of chromatography. While M. Tswett is often credited with the paternity of chromatography, the first traces of the use of ion-exchange chromatography date back to Ancient Egypt where it was used to desalt sea water. Nowadays, industrial...
A new era in life sciences software
The fine chemicals and biochemicals industries will evolve towards more digitally designed processes associating experiments, user know-how and mechanistic modeling
Marc-Olivier Simon, Aline Devoille
"Life sciences industries still use outdated tools and methodologies to develop, optimise and operate their (bio)molecule production processes. Ypso-Facto proposes to take a fresh look at the needs and expectations of this sector. Digitalisation or digital transformation is ubiquitous in discussions...
Ypso-Facto is a service company helping industrial firms to develop, optimize and secure their chemical processes and bioprocesses.
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