Publications

Bioprocess Simulation: Why the Industry Needs To Embrace Engineering Rather Than Empirical Approaches?

By Roger-Marc Nicoud in Bioprocess International

  • by Ypso-Facto
  • March 07, 2024
In 1903, the Wright brothers built the first functioning airplane, and botanist Mikhail Tsvet became the first scientist to use chromatography to separate components of a solution (carotene pigments, in his case). Now, 120 years later, new airplanes can be simulated with great precision and confidence...

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Purification of Protein by HIC

Mechanistic Modeling for Improving Process Optimization

Lucrèce Nicoud, Yohann Le Guennec and Edouard Nicoud from Ypso-Facto; Antonio Cardillo, Alessandro Pieri and Elisa Innocenti from GSK; Elena Lietta from Politecnico di Torino.

  • by Ypso-Facto
  • April 20, 2023
In collaboration with GSK, this article outlines how a simple chromatographic model can predict the impact of pH and ionic strength on HIC chromatograms.   Hydrophobic interaction chromatography (HIC) is a separation technique widely used for the purification of therapeutic proteins. The main...

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CALIPSO: revolutionizing the management of bioproduction processes in healthcare

Paris (France) – September 16th, 2021 – Sanofi, Capgemini, Ypso-Facto, GPC Bio, CEA, CentralSupelec announce the launch of the project CALIPSO !

  • by Ypso-Facto
  • September 16, 2021
  A structuring R&D project for French medical research, financed and coordinated by a consortium of high-profile industrial and public actors. An essential mobilisation to accelerate access to new treatments at an acceptable cost, to ensure France’s competitiveness and its health independence...

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Process comparison in Ypso-Proxima: EASY by Sanofi vs. classical mAb purification process

Technical and economic evaluation to reduce Cost of Goods

Thomas Prouzeau, Jerome Pezzini, and Benoit Mothes

  • by Ypso-Facto
  • January 15, 2021
During the last years, alternatives to Protein A purification in mAb downstream processing have raised substantial interest. In parallel, the pharmaceutical industry has a growing need for reliable tools supporting process development and rational decision-making. This article [1] illustrates the...

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Antibiotics purification by ion-exchange

The power of mechanistic modeling and predictive simulation

Lucrèce Nicoud, Karen-Vanessa Gonzalez, Aude Portier, and Roger-Marc Nicoud

  • by Ypso-Facto
  • November 02, 2020
  Sometimes you have to change a raw material for various reasons (lack of availability, economic pressure, find alternative sustainable raw material), but this little change can impact significantly your process. In the below article, you’ll see how some well-designed experiments and mechanistic...

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Ypso-Facto is a service company helping industrial firms to develop, optimize and secure their chemical processes and bioprocesses.

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